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Periodontal healing following reconstructive surgery: effect of guided tissue regeneration using a bioresorbable barrier device when combined with autogenous bone grafting. A randomized controlled clinical trial
Author(s) -
NygaardØstby Per,
Bakke Vibeke,
Nesdal Oddny,
Nilssen Helene Klerck,
Susin Cristiano,
Wikesjö Ulf M. E.
Publication year - 2008
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2007.01160.x
Subject(s) - medicine , dentistry , surgery , bone grafting , randomized controlled trial , reduction (mathematics) , reconstructive surgery , bone healing , regeneration (biology) , geometry , mathematics , biology , microbiology and biotechnology
Objective: The objective of this randomized‐controlled clinical trial was to evaluate the adjunctive effect of guided tissue regeneration (GTR) using a bioresorbable polylactic acid (PLA) barrier device when combined with autogenous bone grafting in the treatment of deep intra‐bony periodontal defects. Material and Methods: Forty systemically healthy patients (20 females; mean age 53 years; non‐smokers) participated in the study. Using a parallel‐group study design, one intra‐bony defect in each of 20 subjects received GTR using the bioresorbable PLA barrier device (Atrisorb ® ), combined with autogenous bone grafting. One intra‐bony defect in each of the remaining 20 subjects received bone grafting solo (control). Treatments were evaluated at 9 months post‐surgery. Results: One patient (GTR) was withdrawn from the study due to circumstances unrelated to the study. Eighty‐nine per cent of the PLA barriers became exposed within 3 weeks following surgery. Pre‐surgery probing depths for GTR and control intra‐bony defects averaged (±SE) 7.1±0.3 mm. Significant probing depth reduction (2.7±0.3 versus 2.4±0.4 mm), attachment‐level gain (1.7±0.3 versus 1.7±0.5 mm), and bone fill (1.2±0.4 versus 1.2±0.5 mm) were observed for the GTR and control sites, respectively ( p 0.02). However, there were no statistically significant differences between treatment protocols. Conclusions: The results suggest that GTR using the bioresorbable PLA barrier device does not provide additional value to reconstructive surgery including autogenous bone grafting in intra‐bony periodontal defects.