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Inflammatory mediator release following bone grafting in humans: a pilot study
Author(s) -
Preston Rhonda D.,
Meinberg Trudy A.,
Payne Jeffrey B.,
Schmid Marian J.,
Lee HsiMing,
Golub Lorne M.,
Marx David B.,
Reinhardt Richard A.
Publication year - 2007
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2007.01117.x
Subject(s) - mediator , grafting , dentistry , inflammatory mediator , medicine , bone grafting , inflammation , chemistry , organic chemistry , polymer
Aim: The aim of this pilot study was to track markers of periodontal inflammation and bone resorption associated with decalcified freeze‐dried bone allografts. Material and Methods: Eleven subjects completed standardized treatment of intrabony defects 3 mm with allografts. Gingival crevicular fluid was collected from the defect site and an adjacent interproximal site within the surgical field at baseline, 2, 4, and 8 weeks post‐operatively, and analysed for biochemical markers of inflammation/bone resorption. Probing depth, recession, bleeding on probing, plaque, and 6‐month radiographic bone height change were measured. Results: Both prostaglandin E 2 ( p =0.007) and bone‐specific type 1 collagen ( p =0.01) increased in crevicular fluid after 2 weeks in the bone graft sites. Matrix metalloproteinase‐9 levels remained constant over time. There were positive correlations between prostaglandin levels during the first 8 weeks and bone height change over 6 months. Conclusions: Periodontal bone grafts stimulate an inflammatory response during the first 2 weeks post‐operatively, and the potential negative effects of inhibiting prostaglandins post‐operatively should be investigated further.