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A randomized‐controlled trial of low‐dose doxycycline for periodontitis in smokers
Author(s) -
Needleman Ian,
Suvan Jean,
Gilthorpe Mark S.,
Tucker Richard,
St George Geoff,
Giannobile William,
Tonetti Maurizio,
Jarvis Martin
Publication year - 2007
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2007.01058.x
Subject(s) - medicine , randomized controlled trial , chronic periodontitis , doxycycline , periodontitis , statistical significance , placebo , dentistry , clinical trial , surgery , antibiotics , pathology , alternative medicine , microbiology and biotechnology , biology
Background/Aim: Tobacco use reduces the effect of non‐surgical periodontal therapy. Host‐modulation with low‐dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non‐surgical periodontal therapy. Material and Methods: This was a parallel arm, randomized, identical placebo‐controlled trial with masking of examiner, care‐giver, participant and statistician and 6 months of follow‐up. Patients received non‐surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling. Results: Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level −0.19 mm/month (95% CI=−0.34, 0.04; p =0.012) and probing depth 0.30 mm/month (95% CI=−0.42, −0.17; p <0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months. Conclusions: This study does not provide evidence of a benefit of using LDD as an adjunct to non‐surgical periodontal therapy in smokers.