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Gingival crevicular fluid interleukin‐1 β , prostaglandin E 2 and periodontal status in a community population
Author(s) -
Zhong Y.,
Slade G. D.,
Beck J. D.,
Offenbacher S.
Publication year - 2007
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2007.01057.x
Subject(s) - medicine , bleeding on probing , periodontitis , body mass index , confounding , epidemiology , population , periodontal disease , clinical attachment loss , gastroenterology , dentistry , environmental health
Aim: Interleukin‐1 β (IL‐1 β ) and prostaglandin E 2 (PGE 2 ) are key inflammatory mediators involved in periodontal disease. The purposes of this molecular cross‐sectional epidemiological study were to investigate relationships in a community sample between mean concentrations of IL‐1 β and PGE 2 in gingival crevicular fluid (GCF) and (1) clinical periodontal signs and (2) risk factors of host inflammatory response and/or periodontal disease. Material and Methods: The sample comprised 6277 community‐dwelling adults aged 52–74 years enrolled in the Atherosclerosis Risk in Communities (ARIC) study. IL‐1 β and PGE 2 concentrations were measured using enzyme‐linked immunosorbent assay. Person‐level summary variables were computed for maximum pocket depth (MaxPD), maximum clinical attachment level (MaxCAL) and presence/absence of bleeding on probing (BOP). Mean GCF IL‐1 β and PGE 2 concentrations were dependent variables in multiple linear regression models with periodontal measures and covariates as explanatory variables. Results: Both GCF IL‐1 β and PGE 2 were positively related to MaxPD and BOP in multiple regression models ( p <0.01). Increased levels of IL‐1 β and PGE 2 were associated with body mass index 30 kg/m 2 . Conclusion: Higher levels of GCF IL‐1 β and PGE 2 were significantly associated with clinical signs of periodontal disease and independently related to patient‐based anthropomorphic measures, behaviours and exposures in community‐dwelling adults.