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Effect of local antimicrobial agents on excisional palatal wound healing: a clinical and histomorphometric study in rats
Author(s) -
Kozlovsky Avital,
Artzi Zvi,
Hirshberg Avraham,
IsraeliTobias Chen,
Reich Liat
Publication year - 2007
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2006.01033.x
Subject(s) - wound healing , medicine , antimicrobial , dentistry , surgery , microbiology and biotechnology , biology
Aim: To assess the effect of topically applied antimicrobial agents on palatal excisional wound in rats. Materials and Methods: Excisional wounds, 5 mm in diameter, were made in the centre of the palate of 125 Wistar male rats. In four experimental groups, chlorhexidine digluconate (CHX) 0.12% solution, 1% CHX gel, phenolic compounds solution (Listerine ® ), amine/stannous fluoride solution (Meridol ® ) and saline solution as a control group were applied daily for 1 min. The wound area was measured photographically and the epithelialization rate was determined histologically at 3, 7, 14 and 21 days post‐surgery. Results: The mean wound area and mean distance between the epithelial margins decreased significantly with time ( p <0.001) in experimental and control groups, with the greatest wound area reduction and rate of epithelialization on day 14. A significantly superior rate of wound epithelialization ( p =0.03) was presented following use of 1% CHX gel and Listerine ® and a comparatively inferior one when the Meridol ® solution was applied. Conclusions: Each tested antimicrobial agent when applied on an excisional wound with epithelial and connective tissue deficiency did not have a negative effect on the rate of wound closure. The best results were achieved with 1%CHX gel and Listerine ® .