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Effect of rinsing with povidone–iodine on bacteraemia due to scaling: a randomized‐controlled trial
Author(s) -
Cherry Martin,
Daly Christopher G.,
Mitchell David,
Highfield John
Publication year - 2007
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2006.01025.x
Subject(s) - iodine , saline , medicine , viridans streptococci , bacteremia , gingivitis , randomized controlled trial , odds ratio , antiseptic , placebo , dentistry , surgery , anesthesia , streptococcus , chemistry , bacteria , microbiology and biotechnology , biology , antibiotics , pathology , alternative medicine , organic chemistry , genetics
Aim: To investigate rinsing with povidone–iodine on bacteraemia caused by ultrasonic scaling. Material and Methods: Sixty patients with gingivitis undertook a randomized, placebo‐controlled trial in which 30 rinsed with 0.9% saline and 30 with 7.5% povidone–iodine for 2 min. before ultrasonic scaling of FDI teeth 31–35. Blood samples before and after 30 s and 2 min. of scaling were cultured by lysocentrifugation. Results: Oral bacteraemia occurred in 33.3% of the saline group and 10% of the povidone–iodine group. Regression analysis showed that rinsing with povidone–iodine was approximately 80% more effective than rinsing with saline in reducing the occurrence of bacteraemia, with a statistically significant odds ratio (OR) of 0.189 (95% confidence intervals, OR=0.043–0.827). There were 24 oral bacterial isolates in the saline group and 3 in the povidone–iodine group. Viridans streptococci comprised 11 of the isolates in the saline group and none in the povidone–iodine group. Bacteraemia magnitude was 0.1 colony‐forming units /ml in the povidone–iodine subjects and 0.1–0.7 CFU/ml in the saline group. Conclusions: Rinsing with 7.5% povidone–iodine reduced the incidence and magnitude of bacteraemia and eliminated viridans streptococci from such bacteraemia. Povidone–iodine rinsing may be helpful for ultrasonic scaling of gingivitis patients at risk of infective endocarditis.