Premium
Fc γ receptor polymorphisms and periodontal status: a prospective follow‐up study
Author(s) -
Wolf D. L.,
Neiderud A. M.,
Hinckley K.,
Dahlén G.,
Van De Winkel J. G. J.,
Papapanou P. N.
Publication year - 2006
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2006.00973.x
Subject(s) - chronic periodontitis , genotype , periodontitis , medicine , clinical attachment loss , aggressive periodontitis , gastroenterology , periodontal examination , prospective cohort study , antibody , immunology , dentistry , biology , genetics , gene
Aims: The aims of this study were to assess: (i) the distribution of Fc γ receptor polymorphisms among patients with chronic periodontitis (“cases”) and control subjects with no/minimal loss of periodontal tissue support in a Caucasian population; (ii) whether these polymorphisms can serve as severity markers for periodontitis; and (iii) whether they have any bearing on the response to periodontal therapy. Methods: The study sample consisted of 132 cases and 73 controls of comparable age and gender. Full‐mouth periodontal status was assessed. Subgingival plaque (PL) samples and blood samples were obtained and analysed with respect to 19 bacterial species and homologous serum immunoglobulin G titres. Polymorphisms in the Fc γ receptor IIa (131R/H) and IIIb (NA1/NA2) were assessed by polymerase chain reaction. Patients underwent periodontal therapy and were followed up at 4 and 30 months. Results: Neither polymorphism showed a skewed distribution among cases and controls. At baseline, periodontitis patients with Fc γ RIIa‐H/H131 genotype had more PL and deeper pockets than patients in other genotype groups ( p <0.05). Both bacterial levels and antibody titres were unrelated to genotype. The longitudinal analysis failed to detect an association between genotype and response to periodontal therapy. Conclusions: The present data failed to demonstrate a clinically relevant relationship between the Fc γ receptor IIa (131R/H) or IIIb (NA1/NA2) polymorphism and periodontal status.