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Prognostic factors in the treatment of generalized aggressive periodontitis: I. Clinical features and initial outcome
Author(s) -
Hughes Francis J.,
Syed Mahnaz,
Koshy Bindhu,
Marinho Valeria,
Bostanci Nagihan,
McKay Ian J.,
Curtis Michael A.,
Croucher Raymond E.,
Marcenes Wagner
Publication year - 2006
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2006.00966.x
Subject(s) - medicine , logistic regression , aggressive periodontitis , periodontitis , odds ratio , clinical attachment loss , prospective cohort study , dentistry
Aims: The aims of this study were to investigate prognostic factors for initial response to non‐surgical periodontal treatment for generalized aggressive periodontitis. Methods: Seventy‐nine patients with generalized aggressive periodontitis were included in this prospective follow‐up intervention study. Patients' clinical and demographic parameters were collected at baseline and 10 weeks following a standard course of treatment (four visits of non‐surgical root surface debridement together with OHI as required). The relationship between clinical variables and treatment outcome were analysed at site‐specific level by χ 2 analysis and for patient‐specific variables by logistic regression. Results: In general, there was a good response to the treatment provided. In deep sites the mean pocket depth reduction was 2.11±2.01 mm. Site‐specific analysis showed that the presence of plaque had a small but significant predictive effect on outcome (odds ratio 1.4). Sites on teeth with grade II/III mobility showed a significantly reduced response to treatment. Twenty‐five patients were classified as “non‐responders”. Current smoking was strongly associated with non‐responding patients (odds ratio 3.8) in a logistic regression model; plaque, baseline bleeding and initial pocket depth were not significantly associated with treatment outcomes. Conclusions: Overall, the results emphasize the importance of smoking as a negative prognostic factor, and suggest that treatment outcomes may be determined by a wide range of different determinants requiring further study.