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Antibody response after single‐visit full‐mouth ultrasonic debridement versus quadrant‐wise therapy
Author(s) -
Wang Dongqing,
Koshy Geena,
Nagasawa Toshiyuki,
Kawashima Yoko,
Kiji Makoto,
Nitta Hiroshi,
Oda Shigeru,
Ishikawa Isao
Publication year - 2006
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2006.00963.x
Subject(s) - medicine , treponema denticola , debridement (dental) , avidity , quadrant (abdomen) , porphyromonas gingivalis , actinobacillus , prevotella intermedia , antibody , chronic periodontitis , periodontitis , dentistry , surgery , immunology
The aim of this study was to compare serum antibody responses to periodontal pathogens after single‐visit full‐mouth ultrasonic debridement and quadrant‐wise therapy. Material and Methods: Thirty‐six subjects with chronic periodontitis were randomized into three groups: quadrant‐wise debridement in four visits, one‐visit full‐mouth debridement with water and with povidone iodine. Blood samples were collected before and immediately after treatment and 1, 3 and 6 months post‐therapy. Serum antibody titres and avidity to Porphyromonas gingivalis , Actinobacillus actinomycetemcomitans , Prevotella intermedia and Treponema denticola were determined by enzyme‐linked immunosorbent assay (ELISA) and thiocyanate ELISA, respectively. Results: IgG titres to P. gingivalis significantly decreased at 1, 3 and 6 months in full‐mouth debridement with water group, while significant reductions were seen only at 3 and 6 months after quadrant‐wise debridement. Both full‐mouth groups showed significant reduction in IgG titres to A. actinomycetemcomitans at 3 and 6 months. Significant increases in antibody avidity to P. gingivalis and A. actinomycetemcomitans were noted 3 months following full‐mouth debridement with povidone. Conclusion: Both full‐mouth and quadrant treatments generally resulted in a decrease in antibody titres and increase in antibody avidity. Full‐mouth debridement induced an earlier reduction of IgG titre to P. gingivalis and A. actinomycetemcomitans , than quadrant‐wise therapy.