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The short vitamin D receptor is associated with increased risk for generalized aggressive periodontitis
Author(s) -
Park Kyung Sook,
Nam Jung Hyun,
Choi Jeomil
Publication year - 2006
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2006.00944.x
Subject(s) - periodontitis , aggressive periodontitis , medicine , vitamin d and neurology , dentistry
Background: Generalized aggressive periodontitis (GAP) exhibits severe inflammation and alveolar bone loss. Vitamin D receptor (VDR) regulates both bone metabolism and inflammation‐related genes, and its polymorphisms and haplotypes may affect the functional activity of the VDR protein in GAP. Objective: We analysed the genetic effect of VDR start codon, intron, and exon polymorphisms, and their haplotypes on the development of GAP. Materials and Methods: The VDR start codon 27823C>T (rs2228570, Fok I), intron 8 60890G>A (rs154410, Bsm I), and exon 9 61968T>C (rs731236, Taq I) polymorphisms were determined by using the polymerase chain reaction–restriction fragment length polymorphism analysis among 93 GAP patients and 143 healthy controls. Results: The VDR start codon 27823 * C/ * C genotype was associated with an increased risk for GAP [odds ratio (OR)=1.83, p =0.028], but the intron 8 60880G>A and exon 9 61968T>C polymorphisms were not associated with GAP. The VDR haplotype homozygote ht1 ( C–G–T ) carrying 27823 * C allele was associated with a 1.8‐fold increased risk of GAP (OR=1.84, p =0.030). Conclusion: These results demonstrate that the short VDR ( 27823 * C/ * C ) protein may influence GAP susceptibility.