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Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis
Author(s) -
Xajigeorgiou Christiana,
Sakellari Dimitra,
Slini Theodora,
Baka Anneta,
Konstantinidis Antonis
Publication year - 2006
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2006.00905.x
Subject(s) - metronidazole , amoxicillin , medicine , treponema denticola , scaling and root planing , aggressive periodontitis , tannerella forsythia , doxycycline , periodontitis , actinobacillus , gingival and periodontal pocket , chronic periodontitis , dentistry , gastroenterology , antibiotics , porphyromonas gingivalis , microbiology and biotechnology , biology , pathology , traditional chinese medicine , honeysuckle , alternative medicine
Aim: To evaluate and compare the effects of adjunctive metronidazole plus amoxicillin, doxycycline and metronidazole on clinical and microbiological parameters in patients with generalized aggressive periodontitis. Material and Methods: Forty‐three patients participated in this randomized clinical trial divided into four groups. Six weeks after scaling and root planning (SRP), groups 1–3 received adjunctive metronidazole, plus amoxicillin, doxycycline and metronidazole respectively, and group 4 acted as controls. Clinical recordings concerning probing depth, probing attachment level and bleeding on probing were performed at baseline, 6 weeks after SRP and 6 months from baseline. Subgingival samples were analysed using the ‘checkerboard’ DNA–DNA hybridization for Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Tannerella forsythia and Treponema denticola . Results: All treatments resulted in improvement of clinical parameters (ANOVA p >0.05). Systemic administration of metronidazole plus amoxicillin or metronidazole resulted in statistically significant greater reduction of the proportion of sites > 6mm than SRP ( z ‐test, p <0.05). These antimicrobials yielded a significant effect on levels of important periodontal pathogens for 6 months. Conclusion: Adjunctive metronidazole plus amoxicillin or metronidazole alone (when A.actinomycetemcomitans is not involved) is effective in deep pockets of aggressive periodontitis patients.