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Supportive periodontal therapy using mechanical instrumentation or 2% minocycline gel: a 12 month randomized, controlled, single masked pilot study
Author(s) -
McColl E.,
Patel K.,
Dahlen G.,
Tonetti M.,
Graziani F.,
Suvan J.,
Laurell L.
Publication year - 2006
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2005.00879.x
Subject(s) - minocycline , medicine , dentistry , randomized controlled trial , instrumentation (computer programming) , gingival and periodontal pocket , periodontitis , periodontal disease , porphyromonas gingivalis , surgery , antibiotics , microbiology and biotechnology , biology , computer science , operating system
Objective: To compare the short‐term performance of subgingival local delivery of 2% minocycline gel and conventional subgingival debridement in supportive periodontal therapy (SPT) patients. Methods: Forty adult patients having completed active treatment for moderate to advanced chronic periodontitis were included in a randomized, controlled, single masked maintenance care pilot study. Sites with residual pocket probing depths 5 mm and bleeding on probing were treated with either minocycline gel ( minocycline‐group ) or scaling and root planing only ( debridement‐group ) at baseline, 3, 6, and 9 months. Clinical and microbiological examinations were performed at baseline, 3, 6, 9, and 12 months. Results: Full‐mouth plaque and bleeding scores remained <10% and <20%, respectively, for both groups throughout the study. In both groups there was a persistent reduction in number of teeth and sites with probing pocket depths 5 mm ( p <0.05) with no significant differences between the groups. The prevalence of Porphyromonas gingivalis , Tannerella forsythia , Treponema denticola , Actinobacillus actinomycetemcomitans , Prevotella intermedia , and Prevotella nigrescens , remained at levels 10 5 in the majority of patients and sites in both groups. Conclusion: This pilot study failed to show a difference between local delivery of 2% minocycline gel as mono‐therapy and traditional subgingival debridement in patients on SPT.