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The combined use of enamel matrix proteins and a tetracycline‐coated expanded polytetrafluoroethylene barrier membrane in the treatment of intra‐osseous defects
Author(s) -
Sipos P. M.,
Loos B. G.,
Abbas F.,
Timmerman M. F.,
Van Der Velden U.
Publication year - 2005
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2005.00754.x
Subject(s) - polytetrafluoroethylene , tetracycline , dentistry , medicine , barrier membrane , enamel paint , nuclear medicine , membrane , materials science , composite material , chemistry , biochemistry , antibiotics
Objectives: The purpose of this split‐mouth study was to evaluate the clinical response of enamel matrix proteins (EMPs, Emdogain Gel ® ) in intra‐osseous defects with or without a combined application of a tetracycline‐coated expanded polytetrafluoroethylene barrier membrane (e‐PTFE, Gore‐Tex ® ). Methods: Twelve pairs of intra‐osseous periodontal defects in 11 patients received the application of EMPs on the exposed root surface (EMP). One of the two defects received randomly, as an adjunct to EMP treatment, a tetracycline‐coated e‐PTFE membrane (MEMP). At baseline, 6‐ and 12‐month probing pocket depth (PPD), clinical attachment level (CAL) and probing bone level (PBL) were measured. Results: After 12 months, the EMP defects showed a significant mean PPD reduction of 2.86±0.75 mm, a mean gain in CAL of 1.28±2.04 mm, a mean PBL gain of 1.63±1.21 mm and a mean increase of recession (REC) of 1.56±2.30 mm. The MEMP defects showed a significant mean PPD reduction of 3.02±1.55 mm, a mean gain in CAL of 1.65±1.29 mm, a mean PBL gain of 1.58±1.92 mm and a mean increase of REC of 1.38±1.63 mm. Except for significantly more post‐operative discomfort at the MEMP sites, no significant differences were found between EMP and MEMP defects. Conclusion: Within the limits of this study, it is concluded that in the treatment of intra‐osseous defects with EMP, the adjunctive use of a tetracycline‐coated e‐PTFE membrane failed to show more gain of CAL and PBL.