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Interleukin‐1 levels in gingival crevicular fluid adjacent to restorations of calcium aluminate cement and resin composite
Author(s) -
Konradsson Katarina,
Van Dijken Jan W. V.
Publication year - 2005
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2005.00698.x
Subject(s) - dentistry , gingivitis , enamel paint , aluminate , cement , composite number , medicine , materials science , composite material
Abstract Objectives: The aim of this clinical study was to intra‐individually compare Class V restorations of a calcium aluminate cement (CAC), resin composite and enamel with respect to the adjacent levels of interleukin (IL)‐1α, IL‐1β and IL‐1 receptor antagonist (IL‐1ra) in gingival crevicular fluid (GCF). The hypothesis was that there are higher IL‐1 levels adjacent to resin composite, compared with CAC and enamel. Materials and methods: In 15 subjects, at least one set of two Class V restorations with subgingival margins, one CAC and one universal hybrid resin composite, and one control surface of enamel were included. In a cross‐sectional study and on days 0, 3 and 7 of an experimental gingivitis study, GCFs were collected with Periopaper for 30 s. The GCF concentrations of IL‐1α, IL‐1β and IL‐1ra were quantified with enzyme linked immunosorbent assays. Results: Neither the cross‐sectional study nor the experimental gingivitis study showed any significant differences in the levels of IL‐1α, IL‐1β and IL‐1ra between CAC, resin composite and enamel sites ( p >0.05). In the cross‐sectional study, low IL‐1 concentrations were observed. The IL‐1 levels increased significantly during the experimental gingivitis. Conclusion: Regardless of CAC or resin composite, the restorations per se did not affect the GCF levels of IL‐1 and IL‐1ra, neither at healthy gingiva, nor at initiation of plaque‐related gingival inflammation.