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Healing of human intrabony defects following regenerative periodontal therapy with an enamel matrix protein derivative alone or combined with a bioactive glass
Author(s) -
Sculean Anton,
Pietruska Malgorzata,
Schwarz Frank,
Willershausen Britta,
Arweiler Nicole B.,
Auschill Thorsten M.
Publication year - 2005
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2004.00635.x
Subject(s) - enamel matrix derivative , medicine , dentistry , chronic periodontitis , periodontitis , enamel paint , regeneration (biology) , biology , microbiology and biotechnology
Aim: The purpose of the present study was to compare clinically the treatment of deep intrabony defects with a combination of an enamel matrix protein derivative (EMD) and a bioactive glass (BG) to EMD alone. Methods: Thirty patients (16 females and 14 males) suffering from advanced marginal periodontitis were included in this prospective, controlled parallel design multicenter study. In each of the patients, one intrabony defect was randomly treated with either EMD+BG (test) or with EMD alone (control). Clinical measurements were recorded at baseline and at 1 year following therapy. Results: No differences in any of the investigated parameters were observed at baseline between the two groups. Healing was uneventful in all patients. At 1 year after therapy, the test group showed a reduction in mean probing depth (PD) from 8.5±1.1 to 4.4±1.2 mm ( p <0.001) and a change in mean clinical attachment level (CAL) from 10.4±1.5 to 7.1±1.5 mm ( p <0.0001). In the control group, the mean PD was reduced from 8.5±1.5 to 4.0±1.6 mm ( p <0.001) and the mean CAL changed from 10.2±2.1 to 6.3±2.2 mm ( p <0.01). In the test group, 12 sites (80%) gained at least 3 mm or more of CAL, whereas in the control group a CAL gain of 3 mm or more was measured at 13 sites (87%). No statistically significant differences in terms of PD reduction and CAL gain were found between the test and the control treatment. Conclusions: Within the limits of the present study it can be concluded that: (i) at 1 year after surgery, both therapies resulted in significant PD reductions and CAL gains, and (ii) the combination of EMD+BG does not seem to additionally improve the clinical results.