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A methodology using subjective and objective measures to compare plaque inhibition by toothpastes
Author(s) -
Claydon N.,
Yates R.,
Labello R.,
Hall C.,
Armstrong R.,
Addy M.
Publication year - 2004
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2004.00610.x
Subject(s) - stain , dentistry , toothpaste , medicine , dental plaque , crossover study , dentifrice , pathology , chemistry , staining , fluoride , placebo , inorganic chemistry , alternative medicine
Objectives: Plaque scoring usually employs subjective indices. The aim was to compare plaque inhibition of three toothpastes using two objective and one subjective measures of plaque. Material and Methods: Formulations were: (1) an experimental anti‐plaque paste (test); (2) an experimental paste (minus active or negative control); and (3) a proprietary anti‐plaque toothpaste product (positive control). The study was a blind, randomised crossover design using a 4‐day, no tooth brushing, plaque regrowth model and involving 22 healthy subjects. After baseline plaque removal, subjects rinsed twice a day with slurries of the allocated paste. On day 5, plaque was scored by index, wet weight and optical density of extracted disclosing solution from the plaque (stain intensity). Results: All data showed the same pattern. There were highly significant subject and treatment effects but not period effects. The positive control was highly significantly more effective in plaque control than the test and minus active experimental formulations, which in turn were not significantly different from each other. There were strong and significant correlations between pairs of scoring methods particularly wet weight and stain intensity. Conclusion: The use of objective methods of plaque alongside conventional subjective indices provided convincing evidence for increased discriminatory power in a study comparing plaque inhibition by toothpastes.