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Lack of association between the TNF α G −308 A promoter polymorphism and periodontal disease
Author(s) -
Folwaczny Matthias,
Glas Jürgen,
Török HelgaPaula,
Mende Monika,
Folwaczny Christian
Publication year - 2004
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2004.00499.x
Subject(s) - allele , chronic periodontitis , periodontitis , medicine , tumor necrosis factor alpha , restriction fragment length polymorphism , periodontal disease , aggressive periodontitis , genotype , allele frequency , gene polymorphism , polymorphism (computer science) , gene , gastroenterology , immunology , biology , genetics
Background: Immunorelevant gene polymorphisms might influence the susceptibility for periodontal disease. The present study assessed the frequency of a promoter polymorphism (−308G‐to‐A) of the tumour necrosis factor (TNF) α gene in patients with periodontitis and controls. Methods: Eighty‐one patients with generalized chronic periodontitis and 80 healthy controls were genotyped for the −308 polymorphism of the TNF α gene by PCR amplification and subsequent restriction fragment length polymorphism analysis. The diagnosis of chronic periodontitis was made for each subject on basis of standardized clinical and radiographic criteria. Results: In patients with peridontitis and controls, the frequency of the TNF α −308 A allele was comparable (19.1% [31/162] versus 13.8% [22/160]; p =0.193). Conclusion: The present study revealed no association between the −308 TNF α gene polymorphism and periodontal disease.