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Les réponses des PMN suivant l’utilisation de 2 membranes GTR biodégradables
Author(s) -
Buchmann Rainer,
Hasilik Andrej,
Heinecke Achim,
Lange Dieter E.
Publication year - 2001
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2001.281110.x
Subject(s) - medicine , buccal administration , molar , dentistry , myeloperoxidase , periodontitis , gastroenterology , inflammation
Objectives: In the present prospective trial, the PMN response following resorbable GTR barrier placement was evaluated in mandibular class II furcation lesions. Materials and Methods: In 10 patients with treated chronic periodontitis, we randomly selected the 1st molars in the mandible with buccal degree II furcation involvement for either polylactic‐citric‐acid‐ester (PLA) or glycolide‐lactic‐copolymer (PGL) GTR membrane therapy. We examined contralateral healthy molar sites as untreated controls. We then evaluated the PMN‐derived inflammatory tissue response at baseline, weekly up to 6 weeks post‐therapy and at 12 and 24 weeks using GCF myeloperoxidase (MPO), beta‐glucuronidase (βG) and beta‐N‐acetyl‐hexosaminidase (βNAH). Results: The enzyme levels increased from baseline to the 6‐week examination. After the 6‐week reappointment, enzyme levels dropped reaching the baseline scores at both the 12‐ and 24‐week visit. At PGL sites, the enzyme levels decreased earlier. Compared with healthy control sites, the MPO, βNAH and βG tests revealed different maximum levels at week 2 and 3 (PGL) and week 4, 5 and 6 (PLA). For both of the barriers the clinical parameters revealed a sustained improvement following therapy. Conclusion: The release of PMN enzymes following placement of bioabsorbable membranes reflects the early soft tissue healing process. Our results suggest that the PMN response is barrier‐dependent with the maximum response occuring at different times. However, the host response did not measureably affect the course of clinical healing.