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A possible association of α 1 ‐antitrypsin deficiency with the periodontal condition in adults
Author(s) -
Fokkema Schelte J.,
Timmerman Mark F.,
Weijden Fridus A.,
Wolffe Gordon N.,
Renggli Heinz H.
Publication year - 1998
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1998.tb02497.x
Subject(s) - clinical attachment loss , bleeding on probing , medicine , periodontitis , gingival and periodontal pocket , gastroenterology , dentistry , serine proteinase inhibitors , serine , endocrinology , enzyme , biology , biochemistry , serine protease , protease
. α 1 ‐antitrypsin (α1AT) is a serum inhibitor of several neutrophil‐derived proteolytic enzymes, the serine proteinases. In certain individuals, a deficiency of this enzyme inhibitor is present, whereby only 10 to 20% of the normal concentration is present in the circulation. The purpose of this study was to evaluate the influence of this α1AT deficiency on the periodontal condition in a case control study 10 patients aged 20–50 years with a mean age of 32 and showing a deficiency of αlAT were randomly selected from a national data bank, which contains persons known to be affected with the αlAT deficiency state. Control subjects were matched for age, gender and socio‐economic status. Full periodontal charting on all subjects was performed on 6 sites per tooth, including probing attachment level, probing depth, bleeding on probing and a plaque score. Analysis of the data revealed no differences with regard to attachment loss between the two groups. The deficiency group showed 9.3% pockets ≥5 mm and the matched control group 5.9%. When these results were covariated with plaque scores, the deficiency group appeared to have a higher number of sites with probing depths ≥5 mm.