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Pre‐transplant gingival hyperplasia predicts severe cyclosporin‐induced gingival overgrowth in renal transplant patients
Author(s) -
Varga E.,
Len M. A.,
Mair L.H.
Publication year - 1998
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1998.tb02432.x
Subject(s) - renal transplant , medicine , hyperplasia , gingival disease , dentistry , kidney
. The relationship between the pre‐transplant periodontal status and the development of post‐transplant gingival overgrowth was investigated in a longitudinal study. The periodontal condition of 35 patients was examined on 2 occasions while they were on the transplant waiting list and then at 4–6, 10–12, 16 and 20 weeks post‐transplant. At each visit the plaque index, the bleeding index and a pocket index (CPITN) were measured. Dental impressions were taken of the pre‐ and post‐transplant gingival condition and used to make stone models which were used to score the gingival overgrowth index (GOI). The patients divided into 3 distinct groups having severe ( n = 13), mild ( n = 16) or no post‐transplant gingival overgrowth ( n =6). Only 1 of the patients had taken cyclosporin prior to inclusion into the study. All the patients who developed severe overgrowth had evidence of gingival hyperplasia before the transplant. There was no difference in the serum cyclosporin levels between the three groups (χ 2 <2.28, p >0.319). Furthermore, there was no statistical difference for any of the periodontal indices. This study indicates that the hyperplastic gingival inflammatory response of some individuals appears to be potentiated by cyclosporin resulting in severe post‐transplant overgrowth. In other patients the same reaction may allow the fibroblastic activity to occur to an extent where it produces a mild clinically apparent overgrowth.