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Gingival fluid IL‐1βin postmenopausal females on supportive periodontal therapy
Author(s) -
Reinhardt Richard A.,
Payne Jeffrey B.,
Maze Connie,
Babbltt Monica,
Nummikoski PIrkka V.,
Dunning David
Publication year - 1998
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1998.tb02409.x
Subject(s) - medicine , periodontitis , dental alveolus , dentistry , menopause , analysis of variance , chronic periodontitis , osteoporosis , alveolar crest
. Posterior interproximal alveolar bone in 59 women, within 5 years after menopause, was assessed at baseline and after 2 years of supportive periodontal therapy (history of moderate/advanced periodontitis) using digitized image analysis. Baseline lumbar spine bone mineral density, smoking status, and yearly serum estradiol (E 2 ) levels also were obtained to group subjects. An additional 16 non‐periodontitis postmenopausal women were followed 2 years for clinical and estrogen status, 2‐min GCF IL–1β levels averaged from 2 baseline periodontal pockets (in periodontitis subjects) and 2 non‐periodontitis sites (in non‐penodontitis and periodontitis subjects) were determined with an enzyme immunoassay, A progressive and stable site were also monitored every 6 months for GCF IL–1β in 15 patients. Results after 2 years indicated that 17 subjects had no posterior interproximal sites losing ≥0.4 mm of alveolar crest bone height, while 13 subjects had ≥3 such sites. Using analysis of variance, none of the above clinical groupings resulted in a significant difference in mean baseline or longitudinal GCF IL–1≥ levels, However, when subjects who lost alveolar crest bone height were considered. E 2 ‐sufficient subjects had significantly depressed baseline GCF IL‐β (in past‐periodontitis sites) compared to E 2 ;‐deficient patients (9.1 ± 2,1 versus 31,7±10.2 pg/2‐min sample. p <0.05), suggesting E 2 influences gingival IL‐lβ production in progressive periodontitis patients.