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Crevicular fluid prostaglandin E 2 levels in periodontitis‐resistant and periodontitis‐susceptible adults
Author(s) -
Heasman P. A.,
Lauffart B. L.,
Preshaw P. M.
Publication year - 1998
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1998.tb02405.x
Subject(s) - chronic periodontitis , medicine , gingivitis , cohort , periodontitis , prostaglandin e , gastroenterology , prostaglandin e2 , dentistry
. The aim of this cross‐sectional study was to determine concentrations of prostaglandin E 2 (PGE 2 ) in gingival crevicular fluid (GCF) in a cohort of periodontal disease‐resistant (PDR) adults with chronic gingivitis but with minimal evidence of bone loss, and to compare these data with GCF‐PGE 2 levels in patients with untreated chronic adult periodontal disease (CAPD), 20 PDR and 35 CAPD subjects with mean (±se) ages 52. 4 (±2.9) and 43, 7 (±1.2) years respectively, were recruited, GCE was sampled from 6 sites in each PDR subject and 4 sites in each CAPD subject. The GCF‐PGE2 concentrations were determined by enzyme immunoassay (Assay Designs), Whole mouth medians of sitespecific GCF‐PGE; concentrations were calculated for each subject. The means of the median GCF‐PGE: concentrations were: PDR 54.94±4.06 ng/ml; CAPD 41.57±2.91 ng/ml ( p =0.009). We hypothesise that the higher concentrations of PGE; in the PDR group may be associated with the proliferating pocket epithelia of the chronic gingivitis. In the CAPD cohort, there were no differences in GCFPGE: concentrations between subgroups of smokers ( n =13), ex‐smokers ( n =11) and non smokers ( n =11), In the PDR cohort, 19/20 subjects were non‐smokers.