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Local delivery of chemotherapeutic agents in periodontal therapy: Has its time arrived? 1
Author(s) -
Finkelman Richard D.,
Williams Ray C.
Publication year - 1998
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1998.tb02395.x
Subject(s) - scaling and root planing , medicine , antimicrobial , periodontal disease , dentistry , anti infective agents , gingival and periodontal pocket , clinical trial , drug delivery , antibiotics , intensive care medicine , periodontitis , chronic periodontitis , chemistry , organic chemistry , biology , microbiology and biotechnology
. The concept of locally‐delivering chemotherapeutic agents to the periodontal pocket as a method to treat periodontal disease has been studied for over 20 years. A number of locally‐delivered chemotherapeutic agents in periodontal therapy are either currently available or under investigation. Clinical efficacy derives from sustained‐release technology to maintain an effective concentration of drug within the periodontal pocket for a clinically relevant length of time. Studied drugs have mainly been antimicrobials, both antibiotics and antiseptics. Most agents have been tested as adjuncts to scaling and root planing: a few have been studied as stand‐alone monotherapies. Collectively, the data indicate that the use of locally‐delivered antimicrobials as adjuncts results in a significant increase in the reduction of probing depth compared with scaling and root planing alone. In other trials, results in reducing probing depth following the use of stand‐alone locally‐delivered antimicrobials have been equivalent to those of scaling and root planing over a specified time. This Symposium was organized to present the current slate‐of‐the‐art with regard to the use of locally delivered antimicrobials in the treatment of periodontal disease, 5 experts in the field who have had considerable experience in studying locally‐delivered antimicrobials presented data. These speakers reviewed the clinical findings regarding efficacy of 5 different antimicrobial agents. An ensuing panel discussion was to consider treatment recommendations for locally‐delivered antimicrobials.