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The inhibitory effect of combining chlorhexidine and hydrogen peroxide on 3‐day plaque accumulation
Author(s) -
Dona B. L.,
Gründemann L. J. M. M.,
Steinfort J.,
Timmerman M. F.,
Weijden G. A.
Publication year - 1998
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1998.tb02385.x
Subject(s) - hydrogen peroxide , chlorhexidine , inhibitory postsynaptic potential , dental plaque , dentistry , medicine , chemistry , pharmacology , microbiology and biotechnology , biochemistry , biology
. In a blind, randomised, 4‐cell, cross‐over study, the effect of rinsing with a perborate solution (1.9 g sodiumperborate‐monohydrate dissolved in 30 ml water bocasan. Oral‐B$$) on the vivo plaque‐inhibiting effect of 0.12$$ chlorhexidme (Oral‐B$$) was examined. After a thorough professional prophylaxis including interdental cleaning. 12 subjects started to rinse according to 4 different regimens: regimen (C‐P‐C): chlorhexidine in the morning, perborate at noon and chlorhexidine in the evening: regimen (CP‐CP): chlorhexidine immediately followed by perborate in the morning and in the evening: regimen (PC‐PC): perborate immediately followed by chlorhexidine in the morning and in the evening: regimen (C‐C): chlorhexidine in the morning and in the evening No further oral hygiene measures were allowed for the next 72 h. After 72 h. the subjects were scored for plaque, and a washout period of 4 days followed: cross‐over was randomly assigned according to a Latin square design. Following this procedure, all subjects went through all 4 regimens. The regimens C‐P‐C and PC‐PC resulted in significantly lower plaque‐scores. 0.27 and 0.28 respectively, than regimen C‐C (0.40). For the regimen CP‐CP, the plaque‐score was 0.28. which was not significantly different from the C‐C regimen. The results suggest a positive interaction between chlorhexidine and hydrogen peroxide. Rinsing with a combination of 0.12% chlorhexidine (Oral‐B$$) and a perborate solution (bocasan Oral‐B$$) can result in more effective short‐term plaque growth inhibition than rinsing with chlorhexidine alone.