Premium
Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats
Author(s) -
Flemmig T. F.,
Milián E.,
Kopp C.,
Karch H.,
Klaiber B.
Publication year - 1998
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1998.tb02356.x
Subject(s) - actinobacillus , porphyromonas gingivalis , metronidazole , amoxicillin , medicine , microbiology and biotechnology , chlorhexidine , dentistry , chronic periodontitis , treponema denticola , periodontitis , pathogen , dental plaque , biology , immunology , antibiotics
. 48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test). Subgingival plaque and swab samples from tongue, tonsils, and buccal mucosa were taken at baseline, 10 days and 3, 6, 9, and 12 months. A. actinomycetemcomitans was detected in the oral cavity, i.e., subgingival plaque and/or mucous membranes. Less frequently in test patients compared to controls at 9 and 12 months ( p <0.01. whereas, the intraoral detection frequency of P. gingivalis was significantly reduced only 10 days following therapy ( p <0.001). At any time after therapy. A. actinomycetemcomitans was not detected intraorally in 5 of 10 (50%) test and 1 of 13 (8%) control patients harboring this pathogen at baseline; P. gingivalis was not detected in only 1 of 18 (6%) test and none of the 17 control patients harboring this pathogen at baseline. Although the data indicated that the assessed antimicrobial therapy may suppress A. actinomycetemcomitans from the entire oral cavity below detectable levels over a minimum of 12 months. P. gingivalis persisted or reoccurred.