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A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients
Author(s) -
Noyan Üikü,
Yilmaz Selçuk,
Kuru Bahar,
Kadir Tanju,
Acar Okan,
Büget Ergene
Publication year - 1997
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1997.tb00485.x
Subject(s) - metronidazole , scaling and root planing , medicine , dentistry , systemic antibiotics , periodontitis , gingivitis , gingival and periodontal pocket , debridement (dental) , clinical efficacy , quadrant (abdomen) , chronic periodontitis , antibiotics , surgery , microbiology and biotechnology , biology
The present study describes results on selected clinical and microbiological parameters obtained by treatment with local (Elyzol®) and systemic (Flagyl®) use of metronidazole alone and/or mechanical subgingival debridement in adult periodontitis. Patients were randomly divided into local and systemic treatment groups each comprising 5 individuals in each of whom 4 sites (one site/quadrant) with a probing depth of mm were selected and treated with separate treatment modalities. The overall treatment design provided 6 different test groups. Groups of quadrants received: (1) scaling and root planing; (2) local metronidazole treatment: (3) systemic metronidazole treatment; (4) local melronidazole combined with scaling and root planing; (5) systemic metronidazole combined with scaling and root planing; (6) no treatment. The microbiological and clinical effects of treatment modalities were monitored over a period of 42 days. All treatments resulted in clinical improvements (gingivitis, probing pocket depth, attachment level) except for the untreated group. Parallel to the clinical changes, all treatments reduced the number of total bacteria and proportions of obligately anaerobic microorganisms. Although both of the combined treatment groups responded to therapy with better resolution of infection than the pure mechanical and pure metronidazole treatments, local metronidazole in combination with scaling and root planing seems to be more effective in terms of producing both clinical and microbial improvements.