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Short‐term effects of triclosan on healing following subgingival scaling
Author(s) -
Furuichi Y.,
Ramberg P.,
Krok L.,
Lindhe J.
Publication year - 1997
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1997.tb00196.x
Subject(s) - dentifrice , scaling and root planing , triclosan , dentistry , medicine , quadrant (abdomen) , bleeding on probing , gingivitis , periodontitis , chronic periodontitis , surgery , chemistry , inorganic chemistry , pathology , fluoride
The present clinical trial was performed to evaluate short‐term effects of a triclosan‐containing dentifrice/gel combination on soft tissue healing, when applied supra‐/sub‐gingivally at periodontal sites treated with scaling and root planing. 16 subjects with moderate penodontitis participated in a 2×2‐week, split‐mouth designed clinical trial. 2 combinations of gel/dentifrice (the test combination containing triclosan) were used. 2 pairs of contralateral sites with probing pocket depth (PPD) ≥ 5 mm, and which bled on probing (BoP +) were selected in each patient as experimental units. A baseline examination included assessments of PPD, BoP, gingival index scores, plaque index scores, and the composition of the subgingival microbiota (dark‐field microscopy). The assigned quadrant was anaesthetized and the teeth exposed to meticulous scaling and root planing. Immediately after the completion of mechanical therapy, either the test or control gel was applied sub‐gingivally at the experimental sites. The volunteer was instructed to brush his/her teeth with an assigned dentifrice and to apply the gel (via a custom‐made stent) supragingivally 2× daily for the following 2 weeks. He/she was recalled on day 7 for a second professional subgingival gel application. Re‐examinations were carried out on days 2, 7 and 14 after treatment. 1‐week wash‐out periods separated the 2 experimental periods. The mean PPD reductions (between days 0 and 14) were 1.8 mm and 1.9 mm for the test and control gel/dentifrice sites. The reduction in BoP and gingival index scores was significantly greater during the test than during the control regimen. No significant differences were observed between the 2 regimens regarding plaque scores and composition of the subgingival microbiota. The findings from the present investigation demonstrated that triclosan, applied both sub‐ and supra‐gingivally reduced soft tissue inflammation following scaling and root planing.