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Generalized prepubertal periodontitis
Author(s) -
Firatli Erhan,
Gürel Nuray,
Efeoǧlu Ahmet,
Cebeci Irfan
Publication year - 1996
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1996.tb01811.x
Subject(s) - immunology , cd3 , flow cytometry , zymosan , cd8 , cd18 , cd19 , receptor , medicine , chemotaxis , periodontitis , monoclonal antibody , peripheral blood , integrin alpha m , lymphocyte , biology , antibody , antigen , biochemistry , in vitro
The clinical and immunological data from 4 patients with generalized prepubertal periodontitis are presented. The peripheral blood neutrophil chemo‐taxis was measured using zymosan activated sera as the chemoattractant. All of the 4 patients have shown depressed neutrophil chemotaxis compared to those of the healthy controls. Peripheral blood lymphocyte subpopulations were analysed by double‐coloured flow cytometry using monoclonal antibodies for the receptors CD2. CD3. CD4. CD8. CD19. CD29, CD45RA +, 34,29dK, CD56, CD11b/CD18. Lymphocytes bearing CD3 receptors showed a significant decrease compared to those of the controls. Natural killer cells were lowered in 3 of the 4 cases. All of the patients showed a higher increase in CD11b/CD18 expression. The evaluation of CDllb/CD18 receptor in peripheral blood leukocytes may be of help explaining the rôle of neutrophils in the pathogenesis of the disease.