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Human gingival crevicular fluid keratin at healthy, chronic gingivitis and chronic adult periodontitis sites
Author(s) -
McLaughlin W. S.,
Kirkham J.,
Kowolik M. J.,
Robinson C.
Publication year - 1996
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1996.tb00554.x
Subject(s) - gingivitis , keratin , saliva , periodontitis , chronic periodontitis , medicine , dentistry , pathology , chemistry
The present study was designed to determine, in a cross‐sectional study, whether there was any relationship between the keratin‐positive material in gingival crevicular fluid and the clinical periodontal status. Keratins were selected as putative indicators of degradation of epithelial cells cytoskeletal proteins. Keratin positive material was determined by enzyme‐linked immunosorbent assay‐in 42 subjects exhibiting clinical sites of health, chronic gingivitis and chronic periodontitis. The concentration of keratin in parotid saliva was also measured for each subject. Keratin concentration in gingival crevicular fluid samples was significantly greater at sites exhibiting signs of gingivitis and periodontitis compared with healthy sites. No differences were detected between sites exhibiting gingivitis and periodontitis. No differences were found between the 3 groups for the saliva keratin‐positive material which was significantly less than that detected in gingival crevicular fluid. These results suggest that gingival crevicular fluid keratin concentration may serve as a marker of gingival damage.