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Effect of pretreatment with ketorolac tromethamine on post‐operative pain following periodontal surgery
Author(s) -
Trombelli Leonardo,
Schincaglia Gian Pietro,
Zangari Francesca,
Scapoli Chiara,
Calura Giorgio
Publication year - 1996
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1996.tb00545.x
Subject(s) - ketorolac tromethamine , ketorolac , medicine , placebo , analgesic , anesthesia , visual analogue scale , adverse effect , periodontal surgery , randomized controlled trial , naproxen , surgery , alternative medicine , pathology
A double‐blind, randomized, single‐dose clinical trial to evaluate the analgesic efficacy of preoperative ketorolac tromethamine administration on periodontal postoperative pain was designed. One group received 20 mg ketorolac immediately before periodontal flap surgery, and the other group received placebo. Naproxen sodium was allowed post operatively as rescue medication. The visual analog scale was used to estimate pain. Postoperative pain was assessed hourly for the first 10 h on the day of surgery, and 4× daily on the 1st and 2nd postsurgical days. Timing and dose of rescue analgesic remedication were also recorded. Results indicated that preoperative treatment with ketorolac significantly reduced initial pain intensity and delayed the onset of postoperative pain as compared to placebo. Incidence and amount of naproxen consumption was similarly small in both ketorolac‐ and placebo‐treated groups. No adverse reactions related to preoperative medication were observed.