Microbiological and immunohistological findings in a patient with Papillon‐Lefére syndrome

The following communication is a case history of an 11 year‐old female patient suffering from Papillon‐Lefére syndrome. Since a massive occurence of A actinomycetemcomilans had been found in the subgingival microflora of the periodomal pockets, the patient was treated with repeated subgingival scaling, with an adjunct Amoxicillin and Metronidazol treatment. A bacteriological examination of the girl's family proved that several brothers and sisters as well as one parent also carried A. actinomycetemcomitans. showing 3 different strains of this bacterium within the family. An immunohistological examination of the gingival tissue showed a massive inflammatory infiltrate which was dominated by plasma cells. The histological investigation of the first molars did not show morphological abnormalities of the root cementum. Posttreatment clinical and radiographical improvement of the periodontal conditions is reported despite the recurrent finding of A. actinomycetemcomitans.