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No detrimental effect of fibrin glue on the regeneration of intrabony defects
Author(s) -
Cortellini Pierpaolo,
Prato Glovan Paolo Pini,
Tonetti Maurizio S.
Publication year - 1995
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1995.tb00829.x
Subject(s) - fibrin glue , medicine , dentistry , granulation tissue , fibrin , cementum , regeneration (biology) , fibrin tissue adhesive , glue , wound healing , surgery , dentin , materials science , biology , immunology , microbiology and biotechnology , composite material
. This controlled clinical trial evaluated the potential of fibrin glue as a biological carrier to locally deliver guided tissue regeneration (GTR) modulators. 2 controlateral, morphologically similar defects were selected in each of 11 patients and randomly assigned to the test (teflon membrane and fibrin glue) and the control treatment (teflon membrane alone). Outcomes were assessed at membrane removal as newly formed granulation tissue and at the 1‐year follow‐up in terms of changes in probing attachment level, probing pocket depth, recession of the gingival margin, probing bone levels and percentage of fill of the intrabony defects. Data confirmed that GTR treatment of deep intrabony defects results in clinically and statistically significant improvements of the clinical parameters. No significant differences, however, were evidenced between the test and the control treatments. It is suggested that, since fibrin glue did not show detrimental effects on GTR, it could be applied as a biological carrier for the delivery of GTR enhancers into the surgical wound.