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Gingival overgrowth induced by nifedipine and cyclosporin
Author(s) -
O'Valle Francisco,
Mesa Francisco,
Aneiros José,
GómezMorales Mercedes,
Lucena Miguel Angel,
Ramírez César,
Revelles Francisco,
Moreno Esther,
Navarro Nieves,
Caballero Trinidad,
Masseroli Marco,
Moral Raimundo García
Publication year - 1995
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1995.tb00810.x
Subject(s) - nifedipine , medicine , calcium channel blocker , ciclosporin , mann–whitney u test , adverse effect , gastroenterology , kidney , urology , calcium
. In this study, we developed a quantitative method with digital image analysis to evaluate the degree of gingival overgrowth (GO), and compared GO in kidney transplant patients treated with cyclosporin A (CsA) ( n =21) or CsA+ nifedipine ( n = 8) and a group of healthy controls ( n = 30). The method was reproducible and reliable. Our findings showed significant differences in papillary and gingival surface between controls and transplant patients treated with GO inducers. Gingival overgrowth index also differed significantly between controls and each patient group ( p < 0.01, Kruskal‐Wallis test). The administration of the calcium channel blocker nifedipine potentiated the adverse effect of CsA: comparison of the morphometric findings revealed significant differences between patients treated with CsA alone and CsA+ nifedipine in papillary area, dental area, and GO index ( p < 0.01, Mann‐Whitney U ‐test). We conclude that the method of image analysis we developed is useful in assessing the degree of GO.