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Amlodipine‐induced gingival overgrowth
Author(s) -
Seymour R. A.,
Ellis J. S.,
Thomason J. M.,
Monkman S.,
Idle J. R.
Publication year - 1994
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1994.tb00318.x
Subject(s) - amlodipine , medicine , angina , calcium channel blocker , pathogenesis , dentistry , calcium , blood pressure , myocardial infarction
Amlodipine is a calcium channel blocker used in the management of angina and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compounded by the patient's existing periodontal condition. In all 3 patients, there was sequestration of amlodipine in their crevicular fluid. The significance of this finding in relation to the pathogenesis of this unwanted effect remains to be elucidated.