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IL‐1 in gingival crevicular fluid following closed root planing and papillary flap debridement
Author(s) -
Reinhardt Richard A.,
Masada Marvin P.,
Johnson Georgia K.,
DuBois Linda M.,
Seymour Gregory J.,
Allison Anthony C.
Publication year - 1993
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1993.tb00400.x
Subject(s) - debridement (dental) , medicine , dentistry , gingival and periodontal pocket , orthodontics , periodontitis
Interleukin (IL)‐1 alpha and beta are cytokines which can mediate inflammatory, bone resorbing. and reparative effects in the periodontium, but few longitudinal data exist exploring their role following periodontal therapy. This study examined gingival crevicular fluid (GCF) concentrations of IL‐1 alpha and TL‐1 beta at sites with shallow sulci (SS) or inflamed moderate/advanced pockets (M/AP) before and 6 months after treatment with closed scaling/root planing (SC/RP) or papillary flap debridement (PFD), all in the same subject ( n =14 patients). No significant differences were noted in IL‐1 alpha or beta concentrations (determined with two‐site enzyme‐linked immunosorbent assays) between SS and M/AP sites at baseline. While both therapies improved clinical parameters of periodontal disease, IL‐1 alpha concentration increased significantly ( p <0.05) in M/AP‐PFD sites 6 months after treatment, but were unchanged in other groups. IL‐1 beta concentrations were numerically lower after therapy, except for a significant increase ( P <0.05) in M/AP‐PFD sites. These data suggest that surgical wound healing in an inflamed, plaque‐infected site (M/AP‐PFD) results in prolonged production of IL‐1, which may be a reflection of the extent of tissue trauma and delayed wound healing. In spite of increased IL‐1 levels, these sites demonstrated significant short‐term improvement in clinical attachment level (+ 1.8 mm, p <0.001) postoperatively.