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The effect of topical metronidazole therapy on experimentally‐induced periodontitis in the beagle dog
Author(s) -
Klinge Björn,
Kuvatanasuhati Jintakorn,
Attström Rolf,
Kalfas Sotos,
Edwardsson Stig
Publication year - 1992
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1992.tb02532.x
Subject(s) - beagle , metronidazole , medicine , placebo , periodontitis , dentistry , gingival and periodontal pocket , antibiotics , pathology , biology , microbiology and biotechnology , alternative medicine
. The present study was performed to assess the effect of topical metronidazole therapy on ligature‐induced periodontitis in beagle dogs. 6 beagle dogs with experimentally‐induced periodontitis on the mandibular 2nd, 3rd and 4th premolars were treated with metronidazole 10% dental paste 2 × daily for 4 weeks in an open placebo‐controlled study using a split‐mouth design. Recordings of probing pocket depth, bleeding on probing and gingival index were performed before commencement of treatment and repeated weekly during the 4‐weeks treatment period. Concurrently, samples for microbiological analysis were collected from 2 of the dogs. The results demonstrated that probing pocket depth, bleeding on probing and gingival index had improved significantly in the metronidazoletreated side compared with the placebo‐treated side. Black pigmented Bacteroides spp. and Spirochetes , present in all samples before treatment, were eliminated from the metronidazole‐treated side after the 1st week of treatment and throughout the treatment period, whereas they were present in all samples from the placebo‐treated side. The result of the present study demonstrates that topical application of metronidazole in a dental paste, improves the clinical features of the experimentally‐induced periodontitis and eliminates some of the micro‐organisms associated with the disease.