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IgG subclass antibodies to Porphyromonas gingivalis in patients with destructive periodontal disease
Author(s) -
Wilton J. M. A.,
Hurst T. J.,
Austin A. K.
Publication year - 1992
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1992.tb01713.x
Subject(s) - subclass , porphyromonas gingivalis , immunology , antibody , periodontitis , medicine , periodontal disease , periodontal pathogen , immunoglobulin g , pathogen
We have estimated by ELISA the levels of IgG subclass antibodies against P. gingivalis strain W83 whole cells in 35 cases of adult periodontitis and 35 age, sex. ethnic origin and plaque index‐matched healthy controls. The mean levels of IgG 1 ( P <0.0003) and IgG 2 ( p <0.0416) were significantly elevated in the cases. Many sera had no detectable IgG 4 antibodies but by categorising IgG 4 responses into high, low and absent, this subclass was more often present ( p 0.002) in the cases. Analysis of the paired differences between cases and controls showed that only IgG 1 ( p 0.0005) and IgG 4 ( p < 0.003) levels were significantly greater in the cases. The data support the role of P. gingivalis as a key pathogen in adult periodontitis and high levels of IgG 4 antibodies might possibly provide a marker of patients with active disease.