Premium
Elevated levels of the IgG2 subclass in serum from patients with a history of destructive periodontal disease
Author(s) -
Wilton J. M. A.,
Hurst T. J.,
Sterne J. A. C.,
Caves J.,
Tilley C.,
Powell J. R.
Publication year - 1992
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1992.tb00652.x
Subject(s) - subclass , periodontitis , periodontal disease , medicine , antibody , antigen , immunology , gingivitis , chronic periodontitis , dentistry
The levels of the 4 subclasses of IgG were estimated in the serum from 35 patients with a history of chronic periodontitis and 35 matched controls. The levels of IgG2 were significantly ( P <0.019) elevated in the patients (3.756 g 1 ‐1 ) compared to the controls (2.882 g 1 ‐1 ). The data suggest that the predominant antibody response to periodontal pathogens in periodontitis may be directed against carbohydrate or glycolipid antigens.