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The effect of a plaque control programme on the incidence and severity of cyclosporin‐induced gingival changes
Author(s) -
Seymour R. A.,
Smith D. G.
Publication year - 1991
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1991.tb01698.x
Subject(s) - medicine , oral hygiene , gingival inflammation , dentistry , gingivitis , gingival enlargement , hyperplasia , incidence (geometry) , physics , optics
The efficacy of plaque control as a means of preventing cyclosporin‐induced gingival overgrowth was assessed in 27 adult renal transplant patients. After baseline examination, patients were randomly allocated to receive intensive oral hygiene instructions, scaling and root planing (OH group) or no treatment (no treatment group). Gingival condition was assessed 6 months after baseline and changes in gingival form were related to various periodontal and pharmacokinetic measures. In both treatment groups, there was a significant increase ( P < 0.05) in gingival hyperplasia scores at 6 months. In the OH group, plaque scores were significantly lower ( P < 0.05) at 6 months, whereas in the no treatment group, a significant increase in plaque scores, gingival inflammation and probing depths was observed at 6 months. Dosages of cyclosporin, whole blood concentrations of cyclosporin, baseline gingival index, hyperplasia scores, and 6‐month plaque index were not important determinants for the increase in gingival overgrowth in both treatment groups. It is concluded that attention to plaque control and the removal of local irritants is of some benefit for the gingival health of cyclosporin‐treated adult renal transplant patients, but these measures alone did not prevent gingival overgrowth. Pharmacokinetic variables of cyclosporin and various periodontal measures were not good predictors of cyclosporin‐induced gingival changes.