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The effect of some chlorhexidine‐containing mouthrinses on salivary bacterial counts.
Author(s) -
Addy Martin,
Jenkins Susan,
Newcombe Robert
Publication year - 1991
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1991.tb01694.x
Subject(s) - chlorhexidine , antimicrobial , medicine , crossover study , saliva , dentistry , regimen , mouth rinse , saline , microbiology and biotechnology , biology , placebo , pathology , alternative medicine
A number of chlorhexidine mouthwashes are available commercially which differ in formulation and regimen of use. As a comparative measure of antimicrobial persistance, this study evaluated the effect of 4 chlorhexidine mouth‐wash formulations on salivary bacterial counts after a single rinse. The study was a randomised single‐examiner blind 5‐way crossover investigation employing a panel of 10 young healthy human volunteers. The 0.12% and 0.2% commercial formulations when rinsed according to the respective manufacturers instructions produced similar large and prolonged reductions in salivary bacterial counts during the 7‐h period. A 0.1% formulation also commercially available produced minimal effects on salivary bacterial counts and was little different to the saline rinse. A reformulated 0.1% rinse, not commercially available at the time of the study, produced significant salivary bacterial count reductions over the 7‐h period albeit to a lesser degree of magnitude than to the 0.2% and 0.12% rinses. The results were consistent with comparative plaque inhibitory' studies of the formulations and suggest that the method is a quick and simple way of screening products for antimicrobial and antiplaque potential.