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An association between long‐term non‐steroidal anti‐inflammatory drug therapy and the severity of periodontal disease
Author(s) -
Heasman P. A.,
Seymour R. A.
Publication year - 1990
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1990.tb01688.x
Subject(s) - medicine , dental alveolus , dentistry , vascularity , gingival and periodontal pocket , bleeding on probing , periodontitis , gingival recession , resorption , gastroenterology , pathology
The present study was undertaken to compare the periodontal status of a group of 50 patients on long‐term non‐steroidal anti‐inflammatory drug (NSAID) therapy with that of an age and sex‐matched group of 42 controls. The mean duration of drug therapy in the study group was 9 years (range 2–30 years). The clinical parameters investigated were plaque index (PI), gingival index (GI), pocket probing depth (PPD), loss of attachment (LOA), gingival recession (GR) and gingival fluid flow (GFF). Long cone periapical radiographs were also taken to score the amount of alveolar bone resorption. Examinations were carried out on 6 Ramfjord teeth in each subject. The results showed that there were no significant differences between the groups for PI, GI, PPD, LOA, GR or alveolar bone resorption. However, a highly significant difference was seen between the gingival fluid flow in the study (16.74±10.61) and control (37.72 ± 28.63) groups ( p < 0.001). It is suggested that this may be associated with the specific effects of NSAIDs in reducing the vascularity and permeability of small blood vessels.