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Juvenile and rapidly progressive periodontitis
Author(s) -
Çelenligil Haviye,
Kansu Emin,
Eratalay Kenan
Publication year - 1990
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1990.tb00014.x
Subject(s) - periodontitis , immunology , immunofluorescence , cd8 , monoclonal antibody , medicine , cd3 , antibody , biology , immune system
Juvenile and rapidly progressive periodontitis are grouped under the heading of early‐onset periodontitis. In recent years, much attention has been devoted to studying immunologic factors in early‐onset periodontitis. This study was designed to investigate peripheral blood lymphocyte subpopulations, natural killer cells and interleukin‐2 receptor positive (IL‐2R +) cells in patients with juvenile and rapidly progressive periodontitis. 38 patients with juvenile and 30 patients with rapidly progressive periodontitis, plus 30 normal healthy control subjects were included in the study. Peripheral blood T‐lymphocytes, helper T‐cells, suppressor T‐cells, HLA‐DR+ cells, and IL‐2R+ cells were determined using appropriate monoclonal antibodies and the indirect immunofluorescence method. B‐lymphocytes were identified using the direct immunofluorescence technique. Both groups of patients had normal numbers of total CD3 + T‐cells, CD4+ helper T‐cells, CD8+ suppressor T‐cells, HLA‐DR+ cells and IL‐2R + cells. Natural killer cells were found to be significantly elevated in both groups. These findings could contribute to the immunopathogenesis of early‐onset periodontitis.