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Systemic metronidazole in the treatment of periodontitis
Author(s) -
Jenkins W. M. M.,
MacFarlane T. W.,
Gilmour W. H.,
Ramsay I.,
MacKenzie D.
Publication year - 1989
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1989.tb01673.x
Subject(s) - metronidazole , bacteroides , medicine , spirochaete , periodontitis , scaling and root planing , dentistry , debridement (dental) , gingival and periodontal pocket , oral hygiene , chronic periodontitis , gastroenterology , antibiotics , microbiology and biotechnology , biology , bacteria , genetics
The present study evaluated the effect of systemic metronidazole on advanced periodontitis in 10 patients with inadequate oral hygiene. Clinical and microbiological observations were made at a total of 173 bleeding pockets of 5 mm depth or more. The clinical observations comprised plaque index scores, dichotomous measurements of gingival redness and suppuration, pocket depths and attachment levels. The microbiological variables investigated were the % spirochaetes, % black‐pigmented Bacteroides species. % facultative streptococci and presence or absence of Bacteroides gingivalis. At baseline, after clinical measurements and microbiological samples had been taken, each patient received a thorough scaling and root planing. After 3 months, the clinical measurements and microbiological sampling were repeated and a 5‐day course of metronidazole was administered while one side of the mouth was scaled and root planed. After a further 3 months, the final measurements and samples were taken. In comparing pre‐and post‐treatment data, the following significant differences were observed: for debridement alone, a reduction in mean % spirochaetes from 11.5% to 4.9% and an increase in mean % streptococci from 4.7% to 8.8%; for metronidazole alone, a 0.3 mm gain in mean attachment level, a 0.4 mm reduction in mean pocket depth and a reduction in the frequency of suppurating sites from 32% to 16%; for debridement plus metronidazole. a 0.2 mm gain in mean attachment level, a 0.5 mm reduction in mean pocket depth and a reduction in mean % spirochaetes from 5.6% to 2.5%. Thus systemic metronidazole, either alone or accompanied by debridement, produced a modest clinical improvement after debridement alone had failed. However, if the P ‐values are adjusted to account for the fact that multiple significance tests have been carried out, only the reduction in % spirochaetes following debridement alone would remain significant. It was concluded that systemic metronidazole could not be justified in the periodontal management of this group of patients.