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Clinical effects of local application of collagen film–immobilized tetracycline
Author(s) -
Minabe Masato,
Takeuchi Kayo,
Tomomatsu Eiko,
Hori Toshio,
Umemoto Toshio
Publication year - 1989
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1989.tb01657.x
Subject(s) - tetracycline , placebo , bacteroides , dentistry , bleeding on probing , placebo group , medicine , gingival and periodontal pocket , periodontitis , gastroenterology , microbiology and biotechnology , antibiotics , pathology , bacteria , biology , alternative medicine , genetics
Tetracycline‐containing cross‐linked collagen film (TC film), or tetracycline‐free placebo film, were locally applied 4 times, at 1‐week intervals, to 33 teeth with periodontal pockets larger than 4 mm, in 11 patients with periodontal disease. The clinical and microbiological effects are summarized, as follows. In the group treated with the TC film, (1) the clinical indices were significantly decreased at the 4th and 7th weeks in comparison with those at the beginning of treatment. In particular, this group showed a significant decrease in the incidence of bleeding as compared with the placebo group at the 4th week. (2) Total counts of bacteria in the periodontal pockets showed an obvious tendency to decrease with time. The proportion of black‐pigmented bacteroides was significantly decreased at the 4th and 7th weeks when compared with the pretreatment value. The extent of decrease in the proportion of spirochetes at both the 4th and 7th weeks was significant compared with the placebo group and the pretreatment value.