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Neutrophil chemotactic behaviour in patients with early‐onset forms of periodontitis
Author(s) -
Kinane D. F.,
Cullen C. F.,
Johnston F. A.,
Evans C. W.
Publication year - 1989
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1989.tb01648.x
Subject(s) - chemotaxis , chemokinesis , periodontitis , in vivo , immunology , medicine , periodontal disease , biology , receptor , microbiology and biotechnology
Despite some reports to the contrary, it is generally assumed that early‐onset forms of periodontal disease (including both juvenile and rapidly progressive periodontitis) are associated with a defect in neutrophil (PMN) chemotactic behaviour. Using the Boyden chamber technique and N‐formyl‐methionyl‐leucyl‐phenylalanine (FMLP) to assess locomotion by the leading front method, we have failed to show any evidence for such depressed PMN locomotion. Indeed, when PMN chemotaxis and chemokinesis are considered in response to a range of chemoattractant doses our results indicate significant enhancement of all but random locomotion. When taken together with other studies, our results suggest that PMNs from patients with early‐onset periodontitis may show abnormal locomotory behaviour which can either be enhanced or reduced in nature. The extent to which these results reflect in vitro methodology is uncertain and, furthermore, their in vivo significance is unclear.