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Metronidazole plus amoxycillin in the treatment of Actinobacillus associated periodontitis
Author(s) -
Winkelhoff A. J.,
Rodenburg J. P.,
Goené R. J.,
Abbas F.,
Winkel E. G.,
Graaff J.
Publication year - 1989
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1989.tb01626.x
Subject(s) - metronidazole , actinobacillus , medicine , periodontitis , amoxicillin , dentistry , gingival and periodontal pocket , aggressive periodontitis , debridement (dental) , antibiotics , microbiology and biotechnology , biology
The potential use of an adjunctive therapy of metronidazole plus cillin for the subgingival elimination of Actinobacillus actinomycetemcomitans in periodontitis patients was investigated. 22 patients participated in this study, 11 with localized juvenile periodontitis (LJP) and 11 with rapidly progressive periodontitis (RPP). 14 patients had received periodontal treatment in the past. All patients were subgingivally infected with A. actinomycetemcomitans. After mechanical subgingival debridement in combination with the antibiotic treatment, elimination of A. actinomycetemcomitans was achieved in all patients but one. With this one exception, clinical improvements were observed in all patients, resulting in reduced pocket probing depths as well as in a significant reduction in bleeding on probing. Re‐examination of 16 patients after 9–11 months revealed that A. actinomycetemcomitans was still undetectable and further clinical improvement was observed. It was concluded that the combination of metronidazole plus amoxycillin is a valuable adjunct to mechanical therapy in A. actinomycetemcomitans associated periodontal infections.