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Efficacy of Perimed® antibacterial system on established gingivitis (I). Clinical results
Author(s) -
Clark W. B.,
Magnusson I.,
Walker C. B.,
Marks R. G.
Publication year - 1989
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1989.tb01031.x
Subject(s) - gingivitis , medicine , dentistry , hydrogen peroxide , scaling and root planing , chronic periodontitis , periodontitis , chemistry , organic chemistry
A 6‐month, double‐blind controlled study was conducted on 101 subjects to determine the effect of Perimed1 R antibacterial system, containing povidone‐iodine (PVP‐I) and hydrogen peroxide (H 2 O 2 ). on established gingivitis. Subjects were randomly assigned to one of 4 treatment groups: PVP‐I/H 2 O 2 , PVP‐I/H 2 O 2 H 2 O 2 /H 2 O or H 2 O. Gingivitis was assessed by the papillary bleeding score (PBS) and plaque by a modified Quigley‐Hein plaque index (PI) at baseline, 3, 12 and 24 weeks. The average baseline PBS and PI for the 4 groups ranged from 2.16–2.31 and 2.87–2.90, respectively. After baseline evaluation, subjects received a supra‐gingival scaling and a subgingival irrigation with their respective rinse. Daily rinses were supervised and subgingival irrigation was repeated every 3 weeks. Duncan's multiple range test determined which groups differed from each other. The mean PI at 24 weeks was lower than at baseline in all groups. PVP‐I had the lowest PI at all time points. The mean PBS at 24 weeks was 1,48 for PVP‐I, 1.62 for H 2 O 2 , 1.88 for H 2 O and 1.34 for PVP‐I/H 2 0 2 , a reduction from baseline of 31%, 27%, 18%, and 38% respectively. The difference between the PBS for PVP‐I/H 2 O 2 and H 2 O control was significant at each evaluation. There was a 70% reduction in sites with PBS > 3 for PVP‐I/H 2 O 2 between baseline and 24 weeks compared to a 34% decrease in the H 2 O group. It was concluded that the use of Perimed R could be a beneficial adjunctive treatment for the prevention and control of gingivitis when used with routine oral hygiene procedures.