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α 2‐macroglobulin in the sera of patients with periodontal disease
Author(s) -
Skalerič Uroš,
Zajšek Peter,
Cvetko Erika,
Lah Tamara,
Turk Vito,
Zalokar Velislava
Publication year - 1987
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1987.tb01544.x
Subject(s) - nephelometry , periodontal disease , macroglobulin , medicine , immunology , gastroenterology , antibody
The concentration of α 2‐macroglobulin (α 2‐M) in the sera of 86 blood donors was measured by laser nephelometry. Plaque index (P1I), gingival index (GI) and probing depth were recorded around all existing teeth. All measured clinical parameters correlated positively with the concentration of α 2‐M in the sera of the examined persons, but statistically significant positive correlation was found only in with the following: average gingival index and α 2‐M concentration in the sera of females and average probing depth and α 2‐M concentration in the sera of all examined females and males. This study supports the hypothesis that in long–standing chronic periodontal disease, the increased levels of proteinases might trigger the synthesis of α 2‐macroglobulin in the host. The role of α 2‐M as a proteinase scavenger and immunosuppressive agent is discussed briefly.