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Clinical immunologic and microbiologic features of active disease sites in juvenile periodontitis
Author(s) -
Mandell Robert L.,
Ebersole Jeffrey L.,
Socransky Sigmund S.
Publication year - 1987
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1987.tb00996.x
Subject(s) - periodontitis , medicine , periodontal disease , disease , juvenile , dermatology , pathology , dentistry , biology , genetics
Eight juvenile periodontitis (JP) patients, with progressing disease were evaluated for clinical, immunologic, and microbiologic features. Clinically, bleeding on probing, pocket depth, and attachment level were unrelated to progressing disease. Only Actinobacilitts actinomycetemcomitans was related to a marked increase in attachment loss when examined on both a site and patient basis. Eikenella corradens was significantly elevated in progressing sites with A. actinomycetemcomitans as opposed to non‐progressing sites harboring A. actinomycetemeomitans. Eikenella corrodent may function synergistically with A. actino‐mycetemcomitans to enhance disease in JP patients. Darkfield microscopy was of no value in distinguishing disease activity. All patients screened had elevated serum IgG levels to the same serolype of A. adinomycetemcomitans as that isolated from the subgingival flora. Other elevated serum IgG responses were noted to various organisms including F. nudeuiuni, B. intermedius, B. gracilus, B. gingivalis and E. corrodent.