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Effect of folate on phenytoin hyperplasia
Author(s) -
Drew Howard J.,
Vogel Richard I.,
Molofsky Walter,
Baker Herman,
Frank Oscar
Publication year - 1987
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.1987.tb00983.x
Subject(s) - phenytoin , medicine , placebo , folic acid , hyperplasia , systemic administration , pharmacology , gastroenterology , epilepsy , pathology , in vivo , microbiology and biotechnology , psychiatry , biology , alternative medicine
There have been some reports that folic acid inhibits phenytoin‐induced gingival hyperplasia. The purpose of this double‐blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin‐induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180‐day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.